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The effect of attenuated Salmonella typhimurium on the tumor epithelium in mouse colorectal cancer model

ABSTRACT: Bacterial cancer therapy (BCT) shows great promise for treatment of solid tumors, yet basic mechanisms of bacterial-induced tumor suppression remain undefined. We aimed to better understand the tumor epithelium-targeted mechanisms of BCT by using mouse models of intestinal tumorigenesis to assess the effectiveness and mechanisms of treatment with aromatase A-deficient Salmonella typhimurium (STm) delivered by oral gavage.

ORGANISM(S): Mus musculus

PROVIDER: GSE136029 | GEO | 2019/08/20

REPOSITORIES: GEO

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Salmonella Typhimurium SL1344 proteogenomics

Project description:We describe how searching chimeric spectra with post-processing including MS²PIP-derived features aids the identification of hypothetical and unannotated proteins. We apply our workflow to the well-characterized human bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) and validate novel protein-coding regions with by ribo-seq translation evidence. We further elaborate how riboproteogenomics is instrumental for reannotating ORFs and the discovery of novel ORFs across bacteria.

2020-10-13 | PXD016377 | Pride

Influence of Autoinducer-2 (AI-2) in Cell-Free Supernatant of Salmonella Typhimurium in Gene Expression of S. Typhimurium

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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation [Single-cell RNA-seq]

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2016-03-31 | GSE72046 | GEO

Time course of the transcriptional response of three porcine intestinal sections to Salmonella typhimurium infection

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