Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia

ABSTRACT: We analyzed small RNA sequencing data from CD5+/CD19+ B cells of a cohort of indolent and aggressive CLL patients compared with CD19+ B-cells of healthy donors. We identified tsRNA signatures in indolent and aggressive CLL vs. normal B-cells; we also found a drastic dysregulation of the expression of mature tRFs in CLL.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138889 | GEO | 2019/11/11

REPOSITORIES: GEO