Genomics

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Differential DNA methylation profiles of HS ILAE type 1 in human temporal lobe epilepsy


ABSTRACT: Purpose:To provide new perspectives for molecular diagnosis of HS subtypes and find new therapeutic targets for the TLE patients with HS ILAE type 1. Methods:DNA methylation was detected by Whole Genome Bisulfite Sequencing (WGBS). The distribution of differentially methylated regions (DMRs) in the whole genome and different functional regions of genes was comprehensively analyzed. Results:A total of 3708 DMRs, including 1171 highly methylated DMRs and 2537 low methylated DMRs. Distinctions were found in the distributions of DMRs in different regions of genes as well. Six hundred and thirty-two DMGs were found in the promoter region. The results of functional enrichment analysis showed that DMR-related genes were mainly enriched in some signal pathways related to axonal growth, neuronal cytoskeleton, neurotransmitter release, synapse reorganization, epileptogenesis, excess synchronization, and hyperexcitability of neurons. Conclusions:This study preliminarily identified the differential DNA methylation profiles of HS ILAE type 1 in patients with TLE, which provides a theoretical basis for further understanding the molecular mechanism and novel biomarkers for subtypes of HS. Overall design: Examination of 3 temporal lobe epilepsy patients with hippocampal sclerosis and 3 temporal lobe epilepsy patients without hippocampal sclerosis.

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: wang zhang  

PROVIDER: GSE140658 | GEO | 2019-11-22

REPOSITORIES: GEO

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