Chromatin states and transcriptome of CD8+ T cells over the course of differentiation

ABSTRACT: The goal of this study is to analyze the contribution of transposable elements (TEs) tocis-regulation in CD8+ T cells. Using a combination of NGS techniques we show that specific subfamilies of TEs are enriched, and distributed in a lineage-specific fashion in core and boundary domains of CD8+T cell enhancers.This study represents the first detailed analysis of the topology and the enhancer domain-associated putative functions of distinct TE types.

ORGANISM(S): Mus musculus

PROVIDER: GSE142151 | GEO | 2020/03/06

REPOSITORIES: GEO