Genomics

Dataset Information

38

Genes induced by VEGF on the chick CAM after 24h


ABSTRACT: We determined gene expression profiles which were induced in the chick chorio-allantoic membrane 24 h after application of recombinant human VEGF. Overall design: Three individual CAMs with clearly visible induction of new capillaries were compared to a pool of three normal CAMs of the same developmental day.

INSTRUMENT(S): [Chicken] Affymetrix Chicken Genome Array

SUBMITTER: Martin Hagedorn  

PROVIDER: GSE14587 | GEO | 2013-12-30

SECONDARY ACCESSION(S): PRJNA111705

REPOSITORIES: GEO

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Publications


Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of the mitotic kinesin KiF11/Eg5 are a promising new class of anti-neoplastic agents currently evaluated in clinical cancer trials for solid tumors and hematological malignancies. Here we report induction of Eg5 and four other mitotic kinesins including KIF20A/Mklp2 upon stimulation of in vivo ang  ...[more]

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