Genomics

Dataset Information

0

ClpV3 affects pathogenicity in Pseudomonas aeruginosa


ABSTRACT: ClpV3 is a cytoplasmic AAA+ ATPase protein and is an essential component of H3-T6SS in Pseudomonas aeruginosa. Here, we report that an H3-T6SS deletion mutant PAO1(ΔclpV3) significantly affected the virulence-related phenotypes including pyocyanin production, biofilm formation, proteolytic activity and motilities. Most interestingly, the expression of T3SS genes was markedly affected, indicating a strong link between H3-T6SS and T3SS. RNA-Sequencing was performed to globally identify the genes differentially expressed when H3-T6SS was inactivated and the results obtained could be well correlated to the observed phenotypes. Overall design: Gene expression was compared between wild-type P. aeruginosa PAO1 and clpV3 deletion mutant.

INSTRUMENT(S): Illumina HiSeq 2500 (Pseudomonas aeruginosa PAO1)

ORGANISM(S): Pseudomonas aeruginosa PAO1  

SUBMITTER: Kangmin Duan  

PROVIDER: GSE148116 | GEO | 2020-04-20

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE148116_PA-vs-Clpv3.genes.annot.xlsx Xlsx
Items per page:
1 - 1 of 1

Similar Datasets

2020-01-01 | S-EPMC7273116 | BioStudies
2015-01-01 | S-EPMC4589678 | BioStudies
2011-01-01 | S-EPMC3019812 | BioStudies
2020-01-01 | S-EPMC7579411 | BioStudies
2013-01-01 | S-EPMC3804575 | BioStudies
2019-01-01 | S-EPMC6532553 | BioStudies
2001-01-01 | S-EPMC100142 | BioStudies
2019-01-01 | S-EPMC6779463 | BioStudies
2014-01-01 | S-EPMC4053335 | BioStudies
2009-01-01 | S-EPMC3815423 | BioStudies