Next Generation Sequencing Facilitates Quantitative Analysis of Msx1-overexpressed and Control C2C12 Cells Transcriptomes
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE150349 | GEO | 2020/10/02
REPOSITORIES: GEO
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Project description:The spatial and temporal control of gene expression during development requires the concerted actions of sequence-specific transcriptional regulators and epigenetic chromatin modifiers, which are thought to function within precise nuclear compartments. However, how these activities are coordinated within the dynamic context of the nuclear environment is still largely unresolved. Here we show that transcriptional repression by the Msx1 homeoprotein coordinates recruitment of Polycomb to genomic targets with localization to the nuclear periphery. We used genome-wide ChIP-Seq analyses to identify genomic binding sites for Msx1 in C2C12 murine myoblast cells.
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