Transcriptomics

Dataset Information

0

Expression profiling in OVCAR8 cells following treatment with relaxin-2 (RLN2)


ABSTRACT: The relaxin-RXFP1 signaling loop promotes survival and proliferation in a panel of high-grade serous ovarian (HGSOC) cancer cell lines. Knockdown of either the relaxin receptor-1(RXFP1) or relaxin-2 (RLN2) decreased growth and tumorigenicity and increased apoptosis in dependent HGSOC cell lines. Transcriptome profiling of relaxin-dependent HGSOC cells using RNA-Seq revealed genes with altered expression levels following relaxin treatment. This included components of the Notch signaling pathway (NOTCH1 and NOTCH3), Wnt signaling (DVL1, LRP5, BCL9) and extracellular matrix regulation (VEGF-A, MMP9, MMP23). Collectively, genes and pathways upregulated by relaxin provide insight into the mechanisms by which it sustains proliferation of dependent cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151280 | GEO | 2020/12/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-05-23 | GSE252607 | GEO
2024-08-31 | GSE275894 | GEO
2018-01-04 | GSE106377 | GEO
2019-05-13 | GSE122710 | GEO
| PRJNA635380 | ENA
2024-07-04 | PXD051230 | Pride
2024-05-10 | GSE244841 | GEO
2024-05-10 | GSE244842 | GEO
2020-08-10 | PXD018805 | Pride
2017-02-13 | PXD005449 | Pride