Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiCLIP, RNA-Seq in HEK293E cells treated with Torin1

ABSTRACT: m6A RNA methylation and transcriptome profiling in were performed HEK293E cells following treatment with Torin1

ORGANISM(S): Homo sapiens

PROVIDER: GSE152633 | GEO | 2021/06/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

miCLIP, RNA-Seq in HEK293E cells treated with Torin1

Project description:miCLIP, RNA-Seq in HEK293E cells treated with Torin1

| PRJNA639865 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type, genome-edited MTOR(G4448A)-p.C1483Y, and Torin1-treated Wild type Translatomics

Project description:We performed rigorous ribosome profiling in genome-edited cell lines with human MTOR point mutations and Torin1 treated cell lines. By obtaining about 10 million bases of sequence cells, we generated genome-wide translatome and transcriptome data of genome-edited MTOR(G4448A)-p.C1483Y and Torin1 treated cell lines

2019-09-11 | GSE129816 | GEO

J774.1 mouse macrophage-like cell line: Control vs. IR or TAM or Torin1

Project description:Transcriptional profiling of J774.1 cells comparing control (DMSO treatment) with IR or TAM or Torin1 treated cells.

2022-02-15 | GSE166821 | GEO

wild-type and gaf1 mutant cells treated with Torin1 or with a combination of caffeine/rapamycin

Project description:Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and ageing. Inhibition of TORC1 leads to a down-regulation of factors that stimulate protein translation, which in turn contributes to longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous transcriptional regulation is less understood. Here we screened fission yeast deletion mutants for resistance to Torin1, which inhibits TORC1 and cell growth. Cells lacking the GATA transcription factor Gaf1 (gaf1Δ) grew normally even in high doses of Torin1. The gaf1Δ mutation shortened the chronological lifespan of non-dividing cells and diminished the longevity triggered by Torin1 treatment. Expression profiling and genome-wide binding experiments showed that, upon TORC1 inhibition, Gaf1 directly up-regulated genes for small-molecule metabolic pathways and indirectly repressed genes for protein translation. Surprisingly, Gaf1 bound to, and down-regulated the tRNA genes, so also functions as a transcription factor for genes transcribed by RNA polymerase III. Thus, Gaf1 controls the transcription of both coding and tRNA genes to inhibit translation and growth downstream of TORC1.

2020-03-02 | E-MTAB-8569 | biostudies-arrayexpress

E-GEOD-27149

Project description:Transcription profiling by array of mouse vaginal samples following adjuvant treatment

2015-09-17 | E-GEOD-27149 | ExpressionAtlas

miCLIP, RNA-Seq, and Ribo-Seq in MOLM13 cells

Project description:We studied the following conditions: m6A RNA methylation in MOLM13 AML cells; METTL3 deficiency on gene expression and translational efficiency

2017-09-18 | GSE98623 | GEO

Effect of feeding on gene expression in HEK-293E cells either treated with Torin1 or not.

Project description:We examined how mTORC1 influences mRNA expression and alternative splicing during a growth response in human embryonic kidney (HEK) 293E cells, in which mTORC1 is not hyperactive. We released a starvation-induced growth arrest by refeeding, then analyzed mRNA levels and alternative splicing events one and four hours later under either control or Torin1 treatment conditions.

2024-11-20 | GSE273388 | GEO

Comparison of transcriptomes between DMSO-5uM and Torin1-5uM treated mouse cumulus-oocyte complexes cultured in vitro for 14h

Project description:We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcriptomes between DMSO- and Torin 1- treated cumulus-oocyte complexes. 3 individual cumulus-oocyte complex samples of DMSO- and Torin1-treated were collected. Comparison was done between DMSO- and Torin1-treated groups.

2016-08-01 | E-GEOD-79862 | biostudies-arrayexpress

E-GEOD-37148

Project description:Transcriptome Profiling following Neuronal and Glial Expression of ALS-linked SOD1 in Drosophila

2015-09-28 | E-GEOD-37148 | ExpressionAtlas

E-MEXP-1276

Project description:Transcription profiling by array of pancreatic cells from C57BL/6 mice following dibenzazepine treatment

2014-07-03 | E-MEXP-1276 | ExpressionAtlas