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STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

ABSTRACT: Cohesin exists in two variants, containing either STAG1 or STAG2. STAG2 is one of the most commonly mutated genes in human cancer, and a major bladder cancer tumor suppressor. Little is known about how its inactivation contributes to tumor development. Here, we analyze the genomic distribution of STAG1 and STAG2 and perform STAG2 loss-of-function experiments using RT112 bladder cancer cells; we then analyze the resulting genomic effects by integrating gene expression and chromatin interaction data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155380 | GEO | 2020/07/30

REPOSITORIES: GEO

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