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The Bromodomain and extraterminal (BET) inhibitor attenuates inflammatory response and cell migration in human microglia

ABSTRACT: We investigated the mechanisms underlying the anti-inflammatory and anti-migratory function and genes targeted by JQ1 in lipopolysaccharide (LPS)-activated human microglia HMC3 cells using RNA sequencing. The BET inhibitor JQ1 attenuates the LPS-induced inflammatory and migratory response. In addition, LPS-induced IRF1 was inhibited by JQ1, and IRF1 suppressed microglial migration by regulating inflammation and migration genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155408 | GEO | 2021/04/28

REPOSITORIES: GEO

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Selectively targeting bromodomain and extraterminal proteins for degradation as a novel anti-glioblastoma strategy [RNA-seq]

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