Transcriptomics

Dataset Information

23

Over expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity


ABSTRACT: The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expression patterns with insulin autoantibody negative NOD. Variation of gene expression patterns in the pancreatic lymph nodes (PLN) issued from E-IAA positive and negative mice have been analyzed by DNA microarrays Overall design: PLN were used from 5 weeks old NOD mice positive for Insulin Autoantibodies and compared with animals negative for Insulin AutoAntibodies

INSTRUMENT(S): [MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Evie Melanitou  

PROVIDER: GSE15582 | GEO | 2009-10-02

SECONDARY ACCESSION(S): PRJNA115587

REPOSITORIES: GEO

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