Genome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls I

ABSTRACT: To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 63 peripheral blood RNA samples from 6 autoantibody-positive children (Case) and their matched controls (Control) were analyzed with Illumina Sentrix WG-6 v2 genome-wide arrays, in order to study the gene expression changes occuring during the pathogenesis of Type 1 diabetes (T1D). Each case child (positive for T1D-specific autoantibodies) was matched with a persistently autoantibody-negative control child, with the same HLA-DQB1 risk category, gender, and place and date of birth. Seroconversion is determined as th

ORGANISM(S): Homo sapiens

SUBMITTER: Henna Kallionpää 

PROVIDER: E-GEOD-30208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress