Genomics

Dataset Information

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Expression data of peritoneal macrophages from Wild-type mouse cultured in control or serine/glycine-depleted medium.


ABSTRACT: Activation of signaling pathways downstream of Toll-like receptor 4 upregulate expression of genes related to serine metabolism. We cultured peritoneal macrophages in control or serine/glycine-depleted medium for 24 hr, stimulated them with LPS (10 ng/ml) for 6 or 12 hr, and collected them to compare the gene expression. Microarray analysis revealed that serine/glycine-depletion in peritoneal macrophages upregulates gene expression of enzymes for serine biosynthesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE156325 | GEO | 2021/03/31

REPOSITORIES: GEO

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