Transcriptomics

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19

Analysis of human myeloma cell lines expressing beta 3 integrin


ABSTRACT: The aim of these experiments was designed to compare gene expression in human myeloma cell lines expressing beta 3 integrin vs counterpart cell lines that do not express beta 3 integrin. Keywords: Gene expression,cell lines, siRNA Overall design: Phenotype characterization of both primary and cultured myeloma plasma cells was assessed by flow cytometry (FACScanto, Becton Dickinson, San Jose, CA) using a panel of MoAbs or antisera to the following markers: CD138, CD38, CD56, k/l chains, CD20, CD44, CD54, alphav and beta3 chains. The microarray analysis was performed on: myeloma bone resorbing cell lines alphav-beta3 positive and the same cell line silenced for the integrins; myeloma non bone resorbing cell lines negative for the expression of avb3.

INSTRUMENT(S): ABI Human Genome Survey Microarray v2.0

ORGANISM(S): Homo sapiens  

SUBMITTER: gabriella rodolico   

PROVIDER: GSE15867 | GEO | 2009-04-29

SECONDARY ACCESSION(S): PRJNA116971

REPOSITORIES: GEO

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