Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy (ATAC-seq)

ABSTRACT: Purpose: There are three goals of this study: 1. To compare the genomic, exome and chromatin accessiblity profiles of the specific engineered fallopian tube cells of high-grade serous tubo-ovarian cancer (HGSC) models (this study) using whole-exome, whole-genome and ATAC-seq sequencing. Methods: Cells were harvested and frozen in culture media containing FBS and 5% DMSO. Cryopreserved cells were sent to Active Motif (Carlsbad, CA) to perform the ATAC-seq assay. Conclusions: We conclude that whole-exome, whole-genome and ATAC-seq characterization would expedite genetic network analyses and permit the dissection of complex biological functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE158800 | GEO | 2026/09/14

REPOSITORIES: GEO