Dataset Information


Transcriptome analysis of myelid cell types (normal and leukemic)

ABSTRACT: Transcriptome analysis of freshly sorted human CD34+ hematopoietic progenitor cells, human CD14+ peripheral blood monocytes and the human cell line U937 Keywords: one-color based gene expression Overall design: Cells used for this study included freshly sorted human CD34+ hematopoietic progenitor cells from two independent healthy male donors, human CD14+ peripheral blood monocytes from three independent healthy male donors and the human cell line U937. Each sample was analysed seperately.


INSTRUMENT(S): Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)

SUBMITTER: Michael Rehli  

PROVIDER: GSE16076 | GEO | 2010-03-31



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General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells.

Gebhard Claudia C   Benner Chris C   Ehrich Mathias M   Schwarzfischer Lucia L   Schilling Elmar E   Klug Maja M   Dietmaier Wolfgang W   Thiede Christian C   Holler Ernst E   Andreesen Reinhard R   Rehli Michael M  

Cancer research 20100209 4

Aberrant DNA methylation at CpG islands is thought to contribute to cancer initiation and progression, but mechanisms that establish and maintain DNA methylation status during tumorigenesis or normal development remain poorly understood. In this study, we used methyl-CpG immunoprecipitation to generate comparative DNA methylation profiles of healthy and malignant cells (acute leukemia and colorectal carcinoma) for human CpG islands across the genome. While searching for sequence patterns that ch  ...[more]

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