Genomics

Dataset Information

0

Gene expression of TCR-alpha/beta CD4- CD8- human T cells


ABSTRACT: The origin and function of human double negative (DN) TCR-alpha/beta T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. Here we provide evidence that human TCR-alpha/beta CD4- CD8- DN T cells derive exclusively from activated CD8+ T cells. Freshly isolated TCR-alpha/beta DN T cells display a distinct gene expression and cytokine production profile. DN cells isolated from peripheral blood as well as DN cells derived in vitro from CD8+ T cells, produce a defined array of pro-inflammatory mediators that includes IL-1, IL-17, IFN-gama, CXCL3, and CXCL2. These results indicate that, upon activation, CD8+ T cells have the capacity to acquire a distinct phenotype that grants them inflammatory capacity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE16130 | GEO | 2009/05/16

SECONDARY ACCESSION(S): PRJNA115023

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-16130 | biostudies-arrayexpress
| E-GEOD-34935 | biostudies-arrayexpress
| E-GEOD-3024 | biostudies-arrayexpress
| E-GEOD-31082 | biostudies-arrayexpress
2012-01-10 | GSE34935 | GEO
2005-07-29 | GSE3024 | GEO
| E-GEOD-24281 | biostudies-arrayexpress
2011-08-10 | GSE31082 | GEO
| E-GEOD-61195 | biostudies-arrayexpress
| PRJNA115023 | ENA