Transcriptomics,Genomics

Dataset Information

25

Gene expression analysis of 6 MCL and 18 CLL patient samples


ABSTRACT: Microarray-based gene expression analysis identified genes differentially expressed in 6 MCL and 18 CLL patient samples compared in independent analyses to CD19 selected healthy donor B-cell samples. Overall design: In this study, a set of 18 CLL patient samples and 6 MCL patient samples was used to acquire expression profiles of a total of 16 441 transcripts, leading to the identification of differentially expressed genes compared to healthy CD19 positive sorted B-cells by Significance Analysis of Microarray data.

INSTRUMENT(S): Illumina human-6 v2.0 expression beadchip (extended)

SUBMITTER: Alexandra Farfsing  

PROVIDER: GSE16411 | GEO | 2010-06-03

SECONDARY ACCESSION(S): PRJNA122867

REPOSITORIES: GEO

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Publications

Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia.

Farfsing A A   Engel F F   Seiffert M M   Hartmann E E   Ott G G   Rosenwald A A   Stilgenbauer S S   Döhner H H   Boutros M M   Lichter P P   Pscherer A A  

Leukemia 20090730 11


The two B-cell non-Hodgkin's lymphoma entities, chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), show recurrent chromosomal gains of 3q25-q29, 12q13-q14 and 18q21-q22. The pathomechanisms affected by these aberrations are not understood. The aim of this study was to identify genes, located within these gained regions, which control cell death and cell survival of MCL and CLL cancer cells. Blood samples collected from 18 patients with CLL and 6 patients with MCL, as well as 6 ce  ...[more]

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