Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

ABSTRACT: We report trancriptional changes between wildtype C57BL/6J and in mice harboring a spontaneous missense mutation in Pdss2 (V117M, Pdss2 kd/kd).

ORGANISM(S): Mus musculus

PROVIDER: GSE164273 | GEO | 2021/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

Project description:To discern whether the same transcriptional signature of mitochondrial dysfunction previously reported in B6.Alb/cre,Pdss2loxP/loxP liver-conditional knockout mice (Peng, Falk et al. PLoS Genetics, 2008 [PMID 18437205]) was present regardless of Pdss2 mutation type, as well as to assess whether pharmacologic therapies modulate expression of particular pathways, genome-wide transcriptional profiling was performed in liver from B6.Pdss2(kd/kd) missense mutant mice on standard chow or supplemented long-term with either probucol or CoQ10. For analysis of lifelong probucol and CoQ10 supplementation effects in B6.Pdss2(kd/kd) missense mutant mice, total RNA was isolated from the livers of B6 mice and from Pdss2(kd/kd) missense mutant mice fed a normal diet, or a diet supplemented with Probucol or CoQ10. Total RNA was individually hybridized to 20 total Illumina Mouse WG-6 v2.0 arrays, which included 5 biological replicates from each of the 4 groupings: untreated B6.Pdss2(kd/kd) missense mutant mice, probucol-treated B6.Pdss2(kd/kd) mice, CoQ10-treated B6.Pdss2(kd/kd) mice, and untreated B6 wild-type mice. Total RNA

2011-06-07 | E-GEOD-27954 | biostudies-arrayexpress

Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

Project description:Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

| PRJNA689783 | ENA

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

2011-06-07 | GSE27954 | GEO

RNA sequencing of mouse podocytes with and without knockdown of Pdss2

Project description:We report trancriptional changes between wildtype mouse immortalized podocytes and compared to podocytes with shRNA-knockdown of Pdss2.

2021-02-01 | GSE164272 | GEO

Five-month-old infants' identification of the sources of vocalizations.

Project description: Not available

| S-EPMC2773978 | biostudies-literature

PIE1-KD

Project description:PIE1-KD

| PRJEB5853 | ENA

PIE2-KD

Project description:PIE2-KD

| PRJEB5867 | ENA

METTL3 KD in HepG2 cells

Project description:To gain insight into possible processes that require m6A for their function, METTL3 was knocked down (KD) in HepG2 cells by siRNA transfections Differential expression analysis of METTL3 KD versus mock-transfected HepG2 cells, in 2 biological replicates

2012-04-25 | E-GEOD-37001 | biostudies-arrayexpress

Automatic facial mimicry in response to dynamic emotional stimuli in five-month-old infants.

Project description: Not available

| S-EPMC5204153 | biostudies-literature

Transcription profiling of rat brain hippocampi of animals fed the ketogenic diet (KD) to provide insight into the anticonvulsant action of KD

Project description:The ketogenic diet (KD) is an anticonvulsant treatment that has been used to manage medically-intractable epilepsies. The KD requires 10-12 days to become maximally effective, suggesting that changes in gene expression are involved in its anticonvulsant action. Using the Affymetrix rat arrays (RAE230A), 6 control samples and 5 KD samples were run.

2007-10-27 | E-GEOD-1155 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data