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SOX2 Mediates Metabolic Reprogramming of Prostate Cancer Cells (ChIP-Seq)

ABSTRACT: To mechanistically define the function of SOX2 in prostate cancer cells and how it contributes to therapeutic resistance, we performed paired SOX2 chromatin immunoprecipitation-sequencing (ChIP-Seq) and RNA-sequencing (RNA-Seq) on a SOX2-positive CRPC cell line, CWR-R1, to determine which genes SOX2 binds and potentially regulates. To identify novel prostate cancer-specific SOX2 gene targets in CRPC cells distinct from known SOX2 stem cell genes, we conducted parallel SOX2 ChIP-Seq and RNA-Seq in the WA01 embryonic stem cell line and compared results to identified SOX2 targets from CWR-R1 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE166183 | GEO | 2022/01/26

REPOSITORIES: GEO

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SOX2 Mediates Metabolic Reprogramming of Prostate Cancer Cells (RNA-Seq)

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