Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring

ABSTRACT: To gain the new insights into the signaling pathways perturbed by 4-Hydroxybenzoic acid (4HBP) exposure in neural stem cells, we performed RNA-seq analysis in Hippocampus-derived primary NSCs. The NSCs were cultured under two conditions: proliferation and differentiation. In each condition, the cells were treated by 1μM 4HBP for 7 days as the treatment group and treated by EtOH (vehicle) as the control group.

ORGANISM(S): Mus musculus

PROVIDER: GSE166506 | GEO | 2021/12/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Maternal Benzophenone Exposure Impairs Hippocampus Development and Cognitive Function in Mouse Offspring.

Project description: Not available

| S-EPMC8655188 | biostudies-literature

Fetal Growth Restriction Impairs Hippocampal Neurogenesis and Cognition via Tet1 in Offspring

Project description:Fetal growth restriction (FGR) increases the risk for impaired cognitive function later in life. However, the precise mechanisms remain elusive. Using dexamethasone-induced FGR and protein restriction-influenced FGR mouse models, we observed learning and memory deficits in adult FGR offspring. FGR induces decreased hippocampal neurogenesis from the early postnatal period to adulthood by reducing the proliferation of neural stem cells (NSCs). We further found a persistent decrease of Tet1 expression in hippocampal NSCs of FGR mice. Mechanistically, Tet1 downregulation results in hypermethylation of the Dll3 and Notch1 promoters and inhibition of Notch signaling, leading to reduced NSC proliferation. Overexpression of Tet1 activates Notch signaling, offsets the decline in neurogenesis, and enhances learning and memory abilities in FGR offspring. Our data indicate that a long-term decrease in Tet1/Notch signaling in hippocampal NSCs contributes to impaired neurogenesis following FGR and could serve as potential targets for the intervention of FGR-related cognitive disorders.

2021-09-15 | GSE143816 | GEO

Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring

Project description:Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring

| PRJNA701110 | ENA

AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function.

Project description: Not available

| S-EPMC8313999 | biostudies-literature

Loss Of Neural Stem Cell O-Glcnacylation Regulates An Age-Related Fate Switch In The Mature Hippocampus

Project description:To gain mechanistic insight into the role of O-GlcNAc in adult hippocampal neural stem cells (NSCs), we treated primary NSCs with a pharmacological inhibitor of Ogt or a lentivirus encoding an shRNA construct targeting Ogt. We determined that loss of O-GlcNAc in NSCs impairs proliferation and activates programs associated with glial differentiation.

2020-08-14 | GSE143388 | GEO

Expression data from the Neural Stem Cells (NSCs) of LPS induced depression mice model treated with Luteolin

Project description:Gene expression profiling reveals a potential role of Luteolin in LPS induced depression model LPS depression induced mice were orally treated with luteolin (10 mg/kg body weight) once per day during 8 consecutive days. Microarray gene expression was conducted for isolated mice Neural Stem Cells (NSCs) . Two mice brain were used for each expermient. The Microarray gene expression was conducted on NSCs and hipocampus from LPS depression induced depression mice (LPS group), LPS depression induced depression mice treated with luteolin(LPS+L group), Normal mice (PBS group) and Normal mice treated with luteolin (PBS+L).

2021-11-24 | GSE181522 | GEO

Comparison of the transcripts in control and Blimp-1-deficient keratinocytes

Project description:We performed microarray analysis to examine the differential gene expression profiles between Prdm1 (Blimp-1)-deleted and control keratinocytes. Keratinocytes isolated from Prdm1-floxed K5-CreER positive (CKO) mice were cultured in the presence of 4OHT to induce deletion of the Prdm1 allele in vitro. Prdm1-floxed K5-CreER positive (CKO) keratinocytes treated with the ethanol solvent control (EtOH) or Prdm1-floxed K5-CreER negative (control) keratinocytes treated with 4OHT or EtOH served as controls. Microarray analyses revealed that there were 93 genes up-regulated and 109 genes down-regulated by more than 2-fold in the CKO + 4OHT group in comparison with the CKO + EtOH, Ctrl + 4OHT or Ctrl + EtOH groups. Several corneocytes-related genes, including Rptn, Lce1f, Krt1 and Lce1d, are significantly down-regulated and several cytokines/chemokines, including Cxcl1, Cxcl2, Cxcl5 and Il24, are significantly up-regulated upon the deletion of Prdm1 in vitro.

2013-04-02 | GSE34586 | GEO

INS1 CAT cells treated with 1μM thapsigargin vs control.

Project description:Transcriptional profiling of INS1 CAT cells treated with 1μM thapsigargin vs control.

2014-12-22 | GSE17150 | GEO

WT MEFs or IRE1α-/- MEFs treated with 1μM thapsigargin vs control

Project description:Transcriptional profiling of WT MEFs or IRE1α-/- MEFs treated with 1μM thapsigargin for 12hrs compared with their corresponding non-treated cells.

2014-12-22 | GSE17151 | GEO

The impact of exposure to serum lipids during in vitro culture on the transcriptome of bovine blastocysts

Project description:EtOH-Lipid form serum have been added in BSA-supplemented SOF during post-compaction development of IVP bovine embryos. Lipid-treated blastocysts were compared with control treated blastocysts (no lipid addition to BSA, EtOH balanced).

2014-01-09 | GSE53905 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data