Genomics

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T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (CUT&RUN)

ABSTRACT: We used an integrated genomics approach to profile and characterize the cistrome of TR-beta, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in a normal thyroid cell line. Our data demonstrates that T3 promotes significant shifts in TR-beta genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168656 | GEO | 2021/04/01

REPOSITORIES: GEO

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