Dataset Information


Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

ABSTRACT: The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. infantum. Keywords: drug resistance Overall design: Two-condition experiment, resistant strain Sb2000.1 vs wild-type. Five biological replicates for each strain, independently grown and harvested. One replicate per array

INSTRUMENT(S): Centre de Recherche en Infectiologie du CHUL_Leishmania 9K array v1.0

ORGANISM(S): Leishmania infantum  

SUBMITTER: Philippe Leprohon  

PROVIDER: GSE16965 | GEO | 2009-08-15



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