Transcriptomics,Genomics

Dataset Information

15

Expression profiles of two epiblast stem cell lines and one ES cell line


ABSTRACT: This analysis compares the expression profiles of E3 epiblast stem cells (hybrid background), T9 EpiSCs (129 inbred background), and OG2 ES cells. Overall design: All three lines were grown under their respective standard conditions.

INSTRUMENT(S): Illumina MouseRef-8 v2.0 expression beadchip

SUBMITTER: Boris Greber   

PROVIDER: GSE17131 | GEO | 2010-02-21

SECONDARY ACCESSION(S): PRJNA123647

REPOSITORIES: GEO

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Publications

Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells.

Greber Boris B   Wu Guangming G   Bernemann Christof C   Joo Jin Young JY   Han Dong Wook DW   Ko Kinarm K   Tapia Natalia N   Sabour Davood D   Sterneckert Jared J   Tesar Paul P   Schöler Hans R HR  

Cell stem cell 20100301 3


Mouse epiblast stem cells (EpiSCs) are cultured with FGF2 and Activin A, like human embryonic stem cells (hESCs), but the action of the associated pathways in EpiSCs has not been well characterized. Here, we show that activation of the Activin pathway promotes self-renewal of EpiSCs via direct activation of Nanog, whereas inhibition of this pathway induces neuroectodermal differentiation, like in hESCs. In contrast, the different roles of FGF signaling appear to be only partially conserved in th  ...[more]

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