Transcriptomics

Dataset Information

0

Proliferating microglia exhibit unique transcriptional and functional alterations in Alzheimer’s disease


ABSTRACT: Proliferation of microglia represents a physiologically process which is accelerated in several neurodegenerative disorders including Alzheimer disease. The effect of such neurodegeneration-associated microglial proliferation on function and disease progression remains unclear. We hypothesized that microglial proliferation into a neurodegenerative environment generates subpopulations displaying transcriptional and functional changes that may contribute to the transition from acute to chronic neuroinflammation. Here, we show that proliferation results in profound alterations of cellular function by providing evidence that newly proliferated microglia show impaired beta-amyloid clearance in vivo. Through sorting of proliferating microglia of APP/PS1 mice and subsequent transcriptome analysis, we define unique proliferation-associated transcriptomic signatures that change with age and beta-amyloid accumulation and are characterized by an enrichment of immune system-related pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE173453 | GEO | 2025/06/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-02-25 | GSE160523 | GEO
2024-01-17 | GSE249611 | GEO
2024-09-16 | GSE277167 | GEO
2024-04-01 | GSE226938 | GEO
2024-04-01 | GSE226937 | GEO
2014-04-30 | E-MTAB-2121 | biostudies-arrayexpress
2020-06-09 | PXD016075 | Pride
2024-09-30 | GSE235179 | GEO
2023-11-22 | E-MTAB-13360 | biostudies-arrayexpress
2020-05-01 | GSE147495 | GEO