Transcriptomics,Genomics

Dataset Information

0

Expression data from SW620/sh control and SW620/shMACC1


ABSTRACT: MACC1 is a decisive driver of metastasis. In this data set the expression changes of shRNA mediated knock down is analyzed. We used microarrays to detail the global programme of gene expression changing upon MACC1 knock down. Overall design: Cells were collected from in vitro cell of three different passages (as indicated in the sample characteristics field). Between the passages there was one week of cultivation.

INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]

ORGANISM(S): Homo sapiens  

SUBMITTER: Dennis Kobelt  

PROVIDER: GSE175995 | GEO | 2021-12-01

REPOSITORIES: GEO

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Publications

Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells.

Haschemi Reza R   Kobelt Dennis D   Steinwarz Elisabeth E   Schlesinger Martin M   Stein Ulrike U   Bendas Gerd G  

International journal of molecular sciences 20211111 22


Tumor cell crosstalk with platelets and, subsequently, their activation are key steps in hematogenous tumor metastasis. MACC1 is an oncogene involved in molecular pathogenesis of colorectal cancer (CRC) and other solid tumor entities, mediating motility and metastasis, making MACC1 an accepted prognostic biomarker. However, the impact of MACC1 on platelet activation has not yet been addressed. Here, we investigated the activation of platelets by human CRC cells upon MACC1 modulation, indicated b  ...[more]

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