Ontology highlight
ABSTRACT:
INSTRUMENT(S): [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]
ORGANISM(S): Homo sapiens
SUBMITTER: Dennis Kobelt
PROVIDER: GSE175995 | GEO | 2021-12-01
REPOSITORIES: GEO
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Haschemi Reza R Kobelt Dennis D Steinwarz Elisabeth E Schlesinger Martin M Stein Ulrike U Bendas Gerd G
International journal of molecular sciences 20211111 22
Tumor cell crosstalk with platelets and, subsequently, their activation are key steps in hematogenous tumor metastasis. MACC1 is an oncogene involved in molecular pathogenesis of colorectal cancer (CRC) and other solid tumor entities, mediating motility and metastasis, making MACC1 an accepted prognostic biomarker. However, the impact of MACC1 on platelet activation has not yet been addressed. Here, we investigated the activation of platelets by human CRC cells upon MACC1 modulation, indicated b ...[more]