Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide maps of chromatin state in DEAF1 overexpression (OE in Multiple Myeloma)

ABSTRACT: The overexpression of DEAF1, tagged with DYKDDDDK, connnected with the promoter of RAD50.

ORGANISM(S): Homo sapiens

PROVIDER: GSE178328 | GEO | 2025/06/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-wide maps of chromatin state in DEAF1 overexpression (OE in Multiple Myeloma)

Project description:Genome-wide maps of chromatin state in DEAF1 overexpression (OE in Multiple Myeloma)

| PRJNA738501 | ENA

Genome-wide maps of transcription in DEAF1 overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:Genome-wide maps of transcription in DEAF1 overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

| PRJNA739089 | ENA

Genome-wide maps of transcription in DEAF1 overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:We found different genes change between WT and OE cells.

2025-06-15 | GSE178442 | GEO

Genome-wide maps of chromatin state in AIMP1 overexpression (OE) and wildtype (WT) cells in multiple myeloma

Project description:We found Acetyl-H3 was upregulated when AIMP1 overexpressed. Then, we used CHIP-seq to find binding-DNA with acetyl-H3 protein.

2021-12-01 | GSE162742 | GEO

FOXO-regulated Deaf1 controls muscle regeneration through autophagy

Project description:We performed RNAi screens to identify regulators of muscle regeneration. We identified Deaf1 and hypothesized that this transcription factor may regulate autophagy and in turn control myogenesis. We therefore performed chromatin-immunoprecipitation followed by next-generation sequencing (ChIP-seq) to identify Deaf1 downstream targets. The results suggest that Deaf1 binds to the promoters the multiple ATG genes, suppressing their transcription.

2024-05-15 | GSE237088 | GEO

Differential gene expression in the Pancreatic lymph node of Deaf1 knockout mice vs. wild type littermate controls

Project description:Gene expression in the the pancreatic lymph node of 4, 12, and 30 week old Deaf1-knockout (KO) mice compared to BALB/c littermate controls. Gene expression was measured in the pancreatic lymph nodes of 4 wk old Deaf1 KO mice (2 replicates), 12 wk old Deaf1-KO mice (3 replicates), and 30 wk old Deaf1-KO mice (3 replicates).

2011-08-31 | E-GEOD-29153 | biostudies-arrayexpress

Genome-wide maps of transcription in GART overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:We found different genes change between WT and OE cells.

2025-01-01 | GSE222866 | GEO

Genome-wide maps of transcription in PNPO overexpression(OE) and wildtype(WT) cells in Multiple Myeloma

Project description:We found different genes change between WT and OE cells.

2023-06-15 | GSE181017 | GEO

Role of Eif4g3 and Deaf1 in Lymph node

Project description:This SuperSeries is composed of the following subset Series: GSE29152: Lymph node stromal cells: Control siRNA treated vs. Eif4g3 siRNA treated GSE29153: Differential gene expression in the Pancreatic lymph node of Deaf1 knockout mice vs. wild type littermate controls Refer to individual Series

2011-08-31 | E-GEOD-29167 | biostudies-arrayexpress

Gene expression in the pancreatic lymph node of Deaf1 knock out mice vs. BALB/c controls

Project description:A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a breakdown in peripheral tolerance which is controlled by peripheral tissue antigen (PTA) expression in lymph nodes. Here, we identified a transcriptional regulator, deformed epidermal autoregulatory factor 1 (Deaf1), which regulates the expression of various PTAs in the pancreatic lymph node (PLN). We found, by microarray, that Deaf1 controls the expression of ~600 genes in the PLN. In the non-obese diabetic (NOD) mouse model of T1D, we identified a wild-type form of Deaf1 (DF1) and a truncated alternatively spliced variant (DF1-VAR1) that hetero-dimerizes with and decreases the transcriptional activity of DF1. The expression of DF1 correlates with the expression of various pancreatic PTAs such as insulin, and during the onset of destructive insulitis in NOD mice, DF1 expression is downregulated, while the DF1-VAR1 expression is upregulated in the PLN. A reduction in DF1-controlled PTA expression in the PLN, leading to decreased peripheral tolerance, could underlie the pathogenesis of NOD disease.

2009-07-15 | GSE13163 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data