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The chromatin accessibility change by PRC2 inactivation with or without IFNγ stimulation in human MPNST cancer cells

ABSTRACT: PRC2-isogenic human malignant peripheral nerve sheath tumor (MPNST) M3 cells were generated through CRISPR/Cas9-mediated knockout of the PRC2 core component, SUZ12. PRC2 loss led to not only significant increase, but also significant decrease of chromatin accessibility at 15,346 (16% of all ATAC peaks) and 20,099 genomic loci (21% of all ATAC peaks), respectively. PRC2 loss decreased the chromatin accessibility for IFNγ-responsive loci in M3 cells, resulting in dampened response to IFNγ stimulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE179699 | GEO | 2022/08/17

REPOSITORIES: GEO

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