Dataset Information


Intratumoral injection of CpG1826

ABSTRACT: To determine the effect on gene expression of intratumoral injection of the Toll-like receptor agonist CpG1826. MC38 colon cancer cells were injected subcutaneously into C57BL/6 mice and allowed to establish until ~40 mm2. Overall design: 5 CpG1826-treated samples were analyzed and compared to 5 PBS-injected control tumors.

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Michael Henry Kershaw  

PROVIDER: GSE18203 | GEO | 2009-09-23



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Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice.

Westwood Jennifer A JA   Haynes Nicole M NM   Sharkey Janelle J   McLaughlin Nicole N   Pegram Hollie J HJ   Schwendener Reto A RA   Smyth Mark J MJ   Darcy Phillip K PK   Kershaw Michael H MH  

Clinical cancer research : an official journal of the American Association for Cancer Research 20091201 24

PURPOSE: To determine the antitumor activity of a novel combination of two immunomodulatory agents that simultaneously direct multiple components of immunity against cancer. EXPERIMENTAL DESIGN: We combined the Toll-like receptor agonist CpG 1826 with a T-cell costimulatory antibody specific for CD137 in an optimal treatment route and dosing schedule against established tumors in two mouse models. Mechanistic insight was gained using gene-deficient mice and cell-depleting antibodies. RESULTS: Th  ...[more]

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