Dataset Information


DNA copy number data from the CTCR-OV01 study

ABSTRACT: All patients with suspected ovarian cancer (Raised CA 125 and a complex pelvic mass in a perimenopausal woman) were radiologically staged using CT scan and a chest x-ray. Patients with evidence of intra-abdominal metastasis and/or malignant pleural effusion were approached for entry to the study. Tissue biopsy was obtained either under radiological control (core needle biopsy) or via laparoscopic surgery (punch biopsy). Patients with histologicaly confirmed epithelial ovarian cancer were randomized to receive either three cycles of carboplatin (AUC 7) or paclitaxel (175 mg/m2). Overall design: Patients with suspected ovarian cancer had a biopsy obtained before and after 3 cycles of either Carboplatin or Paclitaxel.

INSTRUMENT(S): Agilent-013282 Human Genome CGH Microarray 44B (Feature number version)

SUBMITTER: Charlotte K Y Ng 

PROVIDER: GSE18453 | GEO | 2010-02-28



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Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.

Cooke S L SL   Ng C K Y CK   Melnyk N N   Garcia M J MJ   Hardcastle T T   Temple J J   Langdon S S   Huntsman D D   Brenton J D JD  

Oncogene 20100628 35

Resistance to chemotherapy in ovarian cancer is poorly understood. Evolutionary models of cancer predict that, following treatment, resistance emerges either because of outgrowth of an intrinsically resistant sub-clone or evolves in residual disease under the selective pressure of treatment. To investigate genetic evolution in high-grade serous (HGS) ovarian cancers, we first analysed cell line series derived from three cases of HGS carcinoma before and after platinum resistance had developed (P  ...[more]

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