Transcriptomics,Genomics

Dataset Information

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Comparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease


ABSTRACT: We compared transcriptome of monocyte-derived macrophages of 5 patients with GBA-PD (4 L444P/N, 1 N370S/N) and 4 asymptomatic GBA mutation carriers (GBA-carriers) (3 L444P/N, 1 N370S/N) and 4 controls. We also conducted comparative transcriptome analysis for L444P/N only GBA-PD patients and GBA-carriers. Revealed deregulated genes in GBA-PD independently of GBA mutations (L444P or N370S) were involved in immune response, neuronal function. We found upregulated pathway associated with zinc metabolism in L444P/N GBA-PD patients. The potential important role of DUSP1 in the pathogenesis of GBA-PD was suggested. Overall design: 5 patients with GBA-PD and 4 GBA-carriers and also 4 neurological healthy individuals were enrolled for the current study

INSTRUMENT(S): Illumina HiSeq 1500 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Katerina Basharova  

PROVIDER: GSE184956 | GEO | 2021-09-29

REPOSITORIES: GEO

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