Transcriptomics

Dataset Information

0

Transcriptional reprogramming of infiltrating neutrophils drives lung disease in severe COVID-19 despite low viral load


ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing COVID-19 pandemic have caused ∼40 million cases and over 648,000 deaths in the United States alone. Troubling disparities in COVID-19-associated mortality emerged early, with nearly 70% of deaths confined to Black/African-American (AA) patients in some areas, yet targeted studies within this demographic are scant. Multi-omics single-cell analyses of immune profiles from airways and matching blood samples of Black/AA patients revealed low viral load, yet pronounced and persistent pulmonary neutrophilia with advanced features of cytokine release syndrome and acute respiratory distress syndrome (ARDS), including exacerbated production of IL-8, IL-1β, IL-6, and CCL3/4 along with elevated levels of neutrophil elastase and myeloperoxidase. Circulating S100A12+/IFITM2+ mature neutrophils are recruited via the IL-8/CXCR2 axis, which emerges as a potential therapeutic target to reduce pathogenic neutrophilia and constrain ARDS in severe COVID-19.

ORGANISM(S): Homo sapiens

PROVIDER: GSE186267 | GEO | 2022/11/16

REPOSITORIES: GEO

Similar Datasets

2021-10-05 | GSE157789 | GEO
2020-12-01 | GSE149878 | GEO
2022-08-28 | GSE159585 | GEO
2022-03-01 | E-MTAB-10970 | biostudies-arrayexpress
2022-09-07 | GSE203401 | GEO
2024-01-08 | GSE222431 | GEO
2023-09-01 | GSE242127 | GEO
2022-08-31 | GSE169504 | GEO
2021-07-20 | GSE154311 | GEO
2021-02-03 | PXD023834 | Pride