Model-driven design of synthetic N-terminal coding sequences for fine-tuning gene expression in yeast and bacteria

ABSTRACT: N-terminal coding sequences (NCS) are key regulatory elements for fine-tuning gene expression during translation initiation, the rate-limiting step of translation. However, due to complex combinatory effects of NCS biophysical factors and endogenous regulation, designing NCS remains challenging. Herein, we implemented multi-view learning strategy for model-driven generation of synthetic NCS for Saccharomyces cerevisiae and Bacillus subtilis, which are model microorganisms widely used in the laboratory and industry.

ORGANISM(S): Bacillus subtilis Saccharomyces cerevisiae

PROVIDER: GSE186378 | GEO | 2023/10/31

REPOSITORIES: GEO