Genomics

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Differential gene expression in oncostreams and no-oncostreams area in mouse model glioma


ABSTRACT: Our preliminary data demonstrate that malignant gliomas in both human GBM and mouse models display regular anatomical structures, ‘oncostreams’; we interpret these as a manifestation of GBM self-organization. Oncostreams’ presence correlates with tumor malignancy and parenchymal invasion. Molecular signaling pathways that regulate oncostreams’ organization and function, however, remain unknown. We will test the hypothesis that oncostreams’ present in mouse intracranial glioma model have a characteristic transcriptome that differs from surrounding tumor, and to identify critical genes that regulate oncostreams function. Overall design: mRNA profiles of laser microdisection samples of oncotreams and no-oncostreams areas.

INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Maria Luisa Varela  

PROVIDER: GSE188970 | GEO | 2021-11-18

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE188970_RAW.tar Raw
GSE188970_Streams_v_NoStreams_tuxedo.xlsx Xlsx
filelist.txt Txt
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