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Investigation of SARS-CoV-2 variants that escape from cellular immunity in the absence of humoral immunity

ABSTRACT: X-linked agammaglobulinemia (XLA) is a primary immunodeficiency causing a lack of immunoglobulin production. A COVID-19 patient with XLA showed persistent infection for more than 239 days, representing the longest duration yet reported, in whom SARS-CoV-2 evolved increased proliferative capacity. We identify a mutation of SARS-CoV-2 that is responsible for the immune escape from the cellular immunity of this patient, as well as the TCR that could recognize the wild type antigen but not the correspoinding mutant antigen.

ORGANISM(S): Homo sapiens

PROVIDER: GSE190895 | GEO | 2023/05/12

REPOSITORIES: GEO

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