Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Investigation of SARS-CoV-2 variants that escape from cellular immunity in the absence of humoral immunity

ABSTRACT: Investigation of SARS-CoV-2 variants that escape from cellular immunity in the absence of humoral immunity

PROVIDER: PRJNA788889 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17259467_1.fastq.gz	Fastqsanger.gz
	SRR17259467_2.fastq.gz	Fastqsanger.gz
	SRR17259468_1.fastq.gz	Fastqsanger.gz
	SRR17259468_2.fastq.gz	Fastqsanger.gz
	SRR17259469_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Investigation of SARS-CoV-2 variants that escape from cellular immunity in the absence of humoral immunity

Project description:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency causing a lack of immunoglobulin production. A COVID-19 patient with XLA showed persistent infection for more than 239 days, representing the longest duration yet reported, in whom SARS-CoV-2 evolved increased proliferative capacity. We identify a mutation of SARS-CoV-2 that is responsible for the immune escape from the cellular immunity of this patient, as well as the TCR that could recognize the wild type antigen but not the correspoinding mutant antigen.

2023-05-12 | GSE190895 | GEO

Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

Project description:Cytidine diphosphate (CDP)-ethanolamine pathway of phospholipid metabolism coordinates metabolic programming of Tfh cell responses and humoral immunity.

2021-05-26 | GSE147190 | GEO

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity

Project description:Immune cells can metabolize fatty acids (FAs) to generate energy. The source of different fatty acid species, and their impacts on humoral immunity remains poorly understood. Here we report that proliferating B cells require increased amount of monounsaturated fatty acids (MUFA) to maintain mitochondrial metabolism and mTOR activity, and to prevent excessive autophagy and endoplasmic reticular (ER) stress. Furthermore, B cell extrinsic Stearoyl-Coa desaturase (SCD) activity generates endogenous MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

2020-12-02 | GSE162460 | GEO

Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

Project description:Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

| PRJNA613290 | ENA

Venous plexus-associated lymphoid hubs support meningeal humoral immunity

Project description:Venous plexus-associated lymphoid hubs support meningeal humoral immunity

| PRJNA1064095 | ENA

Role of activated PI3K-delta signaling in humoral immunity

Project description:Role of activated PI3K-delta signaling in humoral immunity

| PRJNA720927 | ENA

Venous plexus-associated lymphoid hubs support meningeal humoral immunity

Project description:Venous plexus-associated lymphoid hubs support meningeal humoral immunity

| PRJNA1069101 | ENA

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.

Project description:Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.

| S-EPMC7953441 | biostudies-literature

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.

Project description:Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Crossneutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic.

| S-EPMC7899476 | biostudies-literature

IL-6-mediated endothelial injury impairs anti-viral humoral immunity

Project description:IL-6-mediated endothelial injury impairs anti-viral humoral immunity

| PRJNA1058435 | ENA