Transcriptomics,Genomics

Dataset Information

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RNA-seq analyses of effects of Alpinetin and Zingiberone on hair follicle regeneration


ABSTRACT: The aim of this study was to determine the effects of Alpinetin (AP) on transcriptome profiles of hair follicle regeneration. Depilation was performed on mice back skin. After 24 hours, the depilated area was treated with 3 mg/ml Alpinetin that were dissolved in 65% ethanol once a day. At day 4 post depilation, skin samples without interfollicular epidermis were obtained for RNAseq. We identified 1567 different expression genes between AP and VC group by using an optimized data analysis workflow. Overall design: We separate the back skin of depilated and AP treated mice, which removed epidermics, and identified the genome-wide expression level of each group.

INSTRUMENT(S): Illumina NovaSeq 6000 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Ying Xiao  

PROVIDER: GSE193763 | GEO | 2022-06-08

REPOSITORIES: GEO

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Publications

Alpinetin promotes hair regeneration via activating hair follicle stem cells.

Fan Xiaojiao X   Chen Jing J   Zhang Yajun Y   Wang Siyi S   Zhong Wenqian W   Yuan Huipu H   Wu Xia X   Wang Chaochen C   Zheng Yixin Y   Wei Yuan Y   Xiao Ying Y  

Chinese medicine 20220531 1


<h4>Background</h4>Alopecia affects millions of individuals globally, with hair loss becoming more common among young people.  Various traditional Chinese medicines (TCM) have been used clinically for treating alopecia, however, the effective compounds and underlying mechanism are less known. We sought to investigate the effect of Alpinetin (AP), a compound extracted from Fabaceae and Zingiberaceae herbs, in hair regeneration.<h4>Methods</h4>Animal model for hair regeneration was mimicked by dep  ...[more]

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