Hair Follicle Epithelial Stem Cells Contributing to Interfollicular Epidermis during Homeostasis
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ABSTRACT: The mammalian skin is a crucial barrier, with the epidermis as its protective, renewing outer layer. Loss of epidermal function is lethal, so multiple stem cell populations likely support the interfollicular epidermis (IFE) for survival. We show that KROX20 marks a diverse stem cell population in the upper and middle mouse hair follicle (HF), partially overlapping with known HF stem cells. Lineage tracing reveals that Krox20-lineage cells migrate from the HF to the IFE, contributing to both basal and suprabasal layers. Spatial transcriptomics analysis of the skin was used to confirm this migration.
ORGANISM(S): Mus musculus
PROVIDER: GSE281086 | GEO | 2025/06/26
REPOSITORIES: GEO
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