Transcriptomics,Genomics

Dataset Information

19

CTL differentiation: WT vs. IL-2Ra deficient CTL


ABSTRACT: Gene expression analysis of WT and IL-2Ra-deficient CTL (P14) isolated 8 days after inffection with LCMV. The goals of the study are to assess the impact of IL-2 signals on effector and memory CTL differentiation. Overall design: This is a 2-condition experiement comparing WT P14 Tg T cells eight days after LCMV infection to IL-2Ra-deficient P14 Tg T cells isolated at the same time from the same host. Cells are isolated via FACS-sorting form the spleen.

INSTRUMENT(S): Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)

SUBMITTER: Matthew Williams   

PROVIDER: GSE19598 | GEO | 2009-12-23

SECONDARY ACCESSION(S): PRJNA122385

REPOSITORIES: GEO

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Publications

Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.

Mitchell Diana M DM   Ravkov Eugene V EV   Williams Matthew A MA  

Journal of immunology (Baltimore, Md. : 1950) 20100514 12


IL-2 provides a memory differentiation signal to CD8+ T cells during the primary response that impacts the ability of the subsequent memory pool to mount a successful recall response. In this study, we find that although primary effector CTL development is modestly decreased in the absence of IL-2, the persistence of short-term and long-term effector memory CD8+ T cells on pathogen clearance is greatly diminished. Furthermore, secondary challenge of CD8+ memory T cells lacking the high-avidity I  ...[more]

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