Transcriptomics

Dataset Information

31

Compounds profiling on MCF7


ABSTRACT: The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Overall design: Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibitors: Doxorubicin, SN38 (active metabolite of Irinotecan). The MCF7 cell line was treated with the different compounds for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a control. Two replicates per treatment.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Roberta Bosotti  

PROVIDER: GSE19638 | GEO |

SECONDARY ACCESSION(S): PRJNA123991

REPOSITORIES: GEO

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