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Compounds profiling on MCF7

ABSTRACT: The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19638 | GEO | 2010/07/14

SECONDARY ACCESSION(S): PRJNA123991

REPOSITORIES: GEO

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Compounds profiling on MCF7

Project description:The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibitors: Doxorubicin, SN38 (active metabolite of Irinotecan). The MCF7 cell line was treated with the different compounds for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a control. Two replicates per treatment.

2010-07-14 | E-GEOD-19638 | biostudies-arrayexpress

CDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line

Project description:The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling.

2010-07-14 | GSE18501 | GEO

CDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line

Project description:The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. The MCF7 cell line was treated with PHA-848125 for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a control. Two replicates per treatment.

2010-07-14 | E-GEOD-18501 | biostudies-arrayexpress

microRNA expression profile of MCF7 cells with retroviral inducible expression of ΔNp63α [miRNA]

Project description:MCF7 is a breast adenocarcinoma cell line which exhibits properties of differentiated luminal epithelial cells. ΔNp63α, an N-terminally truncated isoform of p51/p63 protein, plays a critical role in mammary gland development. Here, we inducibly express ΔNp63α in MCF7 cells and studied its role in stemness of breast cancer cells.

2015-12-28 | GSE64954 | GEO

mRNA expression profile of MCF7 cells with retroviral inducible expression of ΔNp63α [total RNA]

2015-12-28 | GSE64953 | GEO

Gene expression profiling in MCF7 cell lines under hypoxia and reoxygenation

Project description:Purpose: Study hypoxia and reoxygenation induced changes in genome-wide gene expression Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we performed a transcriptomics analysis in MCF7 cells subjected to changes in oxygenation (i.e. acute hypoxia, chronic hypoxia, reoxygenation). Results: Global downregulation upon hypoxia; partial restore on reoxygenation. Conclusions: Our data show that oxygen availability dynamically regulates gene transcription.

2016-11-01 | GSE70805 | GEO

Gene expression changes induced by paclitaxel in MCF7 breast cancer cells

Project description:Time-dependent changes in gene expression induced by paclitaxel in the breast adenocarcinoma cell line MCF7. Keywords: genetic modification

2007-12-21 | GSE4298 | GEO

Differential Gene Expression between MCF10A and MCF7 cells

Project description:These RNA-seq data were generated to correlate with genomic interaction data in a related Hi-C analysis. MCF10A is a normal-like mammary epithelial cell line and MCF7 is a transformed estrogen responsive breast cancer cell line derived from a metastatic site; both are commonly used in models of breast cancer progression. Analysis revealed a set of genes related to repression of WNT signalling that were both up-regulated in MCF7 and located in genomic regions that had transitioned from closed to open structure in MCF7.

2015-09-02 | GSE71862 | GEO

H3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia

Project description:Purpose: Study hypoxia induced changes in genome-wide H3K27me3 occupancy Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we combined chromatin-immunoprecipitation and deep-sequencing analysis to identify H3K27me3-marks in MCF7 cells subjected to changes in oxygenation (i.e. acute hypoxia, chronic hypoxia). Results: H3K27me3-marks showed a rapid global increase at specific sites throughout the genome under hypoxia, both genic and inter-genic. Conclusions: Our data show that oxygen availability dynamically regulates the epigenetic state of the genome.

2014-09-26 | GSE61740 | GEO

CDK inhibitors and flavopiridol profiling on A2780 and MCF7 cells

Project description:This SuperSeries is composed of the following subset Series: GSE18486: CDK inhibitors PHA-848125 and PHA-690509 profiling on A2780 GSE18498: CDK inhibitor PHA-793887 profiling on A2780 GSE18501: CDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line GSE18504: Flavopiridol profiling on A2780 GSE19638: Compounds profiling on MCF7 Refer to individual Series

2010-07-14 | E-GEOD-18552 | biostudies-arrayexpress

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