Transcriptomics,Genomics

Dataset Information

19

Global gene expression profile of primary human leukemic blasts


ABSTRACT: The goal of this study is to define the global gene expression profile of primary leukemic blasts from patients with different forms of myeloid leukemia and different FAB subtypes. Here we report the global gene expression profile of 2 patients with AML FAB M5, 2 patients with AML FAB M7, 3 patients with Down syndrome AML FAB M7 and 3 patients with Down syndrome transient leukemia. Overall design: Leukemic blasts were FACS sorted by their immunophenotype and expression profiles were generated by microarray.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Jan-Henning Klusmann   

PROVIDER: GSE19681 | GEO | 2009-12-29

SECONDARY ACCESSION(S): PRJNA122509

REPOSITORIES: GEO

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Publications

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.

Klusmann Jan-Henning JH   Li Zhe Z   Böhmer Katarina K   Maroz Aliaksandra A   Koch Mia Lee ML   Emmrich Stephan S   Godinho Frank J FJ   Orkin Stuart H SH   Reinhardt Dirk D  

Genes & development 20100301 5


Children with trisomy 21/Down syndrome (DS) are at high risk to develop acute megakaryoblastic leukemia (DS-AMKL) and the related transient leukemia (DS-TL). The factors on human chromosome 21 (Hsa21) that confer this predisposing effect, especially in synergy with consistently mutated transcription factor GATA1 (GATA1s), remain poorly understood. Here, we investigated the role of Hsa21-encoded miR-125b-2, a microRNA (miRNA) overexpressed in DS-AMKL/TL, in hematopoiesis and leukemogenesis. We id  ...[more]

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