Dataset Information


Expression data from normal Prostate epithelial cells (PrEC) and the LNCaP cancer cell line

ABSTRACT: To identify genomic regions which display concordant gene expression in prostate cancer, we performed expression profiling of normal prostate epithelial cells (PrEC) and the prostate cancer cell line LNCaP. These expression arrays were integrated ChIP-on-chip studies of active and repressive epigenetic marks in same cells to discover and characterise regions of Long Range Epigenetic Silencing (LRES) in prostate cancer. Overall design: Duplicate expression arrays of PrEC and LNCaP

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Aaron Statham  

PROVIDER: GSE19725 | GEO | 2010-01-04



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Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.

Coolen Marcel W MW   Stirzaker Clare C   Song Jenny Z JZ   Statham Aaron L AL   Kassir Zena Z   Moreno Carlos S CS   Young Andrew N AN   Varma Vijay V   Speed Terence P TP   Cowley Mark M   Lacaze Paul P   Kaplan Warren W   Robinson Mark D MD   Clark Susan J SJ  

Nature cell biology 20100221 3

Silencing of individual genes can occur by genetic and epigenetic processes during carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated prostate cancer epigenome map using tiling arrays, we show that contiguous regions of gene suppression commonly occur through long-range epigenetic silencing (LRES). We identified 47 LRES regions in prostate cancer, typically spanning about 2 Mb and harbouring approximately 12 genes, with a prevalence of tumour suppressor and m  ...[more]

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