Genomics

Dataset Information

16

Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina Genome Analyzer II (Homo sapiens)

SUBMITTER: Iouri Chepelev   

PROVIDER: GSE20072 | GEO | 2010-04-25

SECONDARY ACCESSION(S): GSE20040GSE20071PRJNA124187

REPOSITORIES: GEO

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Publications

Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.

Barski Artem A   Chepelev Iouri I   Liko Dritan D   Cuddapah Suresh S   Fleming Alastair B AB   Birch Joanna J   Cui Kairong K   White Robert J RJ   Zhao Keji K  

Nature structural & molecular biology 20100425 5


Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis al  ...[more]

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