Genomics

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Effect of cardiomyocyte-specific deletion of glucocorticoid receptor on gene expression of the cardiac tissue during early postnatal development


ABSTRACT: To investigate the role of the glucocorticoid receptor (GR) in the regulation of cardiomyocyte maturation and proliferation, we established a cardiomyocyte-specific GR knock-out (GR-cKO) mouse model by Cre-Lox technology. We thus performed gene expression profiling analysis using data obtained from RNA-seq of the cardiac tissue of GR-cKO and control mouse models extracted during the early postnatal development. Our analyses unveiled a role for GR in regulating gene networks related to the energetic metabolism, which in turn may impact on cardiomyocyte proliferative and regenerative ability. Overall design: Comparative gene expression profiling analysis of RNA-seq data of cardiac tissue lysates from GR-cKO and control mouse models at postnatal-day-7 (P7).

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Gabriele D'Uva  

PROVIDER: GSE202969 | GEO | 2022-05-16

REPOSITORIES: GEO

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