Genomics

Dataset Information

19

Salmonella infected Dictyostelium discoideum


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Dictyostelium discoideum cDNA Microarray 6000

SUBMITTER: Ludwig Eichinger   

PROVIDER: GSE20688 | GEO | 2010-03-10

SECONDARY ACCESSION(S): GSE20648GSE20640GSE20644GSE20642GSE20651GSE20632PRJNA124835

REPOSITORIES: GEO

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Publications

Salmonella typhimurium is pathogenic for Dictyostelium cells and subverts the starvation response.

Sillo Alessio A   Matthias Jan J   Konertz Roman R   Bozzaro Salvatore S   Eichinger Ludwig L  

Cellular microbiology 20110914 11


In unicellular amoebae, such as Dictyostelium discoideum, bacterial phagocytosis is a food hunting device, while in higher organisms it is the first defence barrier against microbial infection. In both cases, pathogenic bacteria exploit phagocytosis to enter the cell and multiply intracellularly. Salmonella typhimurium, the agent of food-borne gastroenteritis, is phagocytosed by both macrophages and Dictyostelium cells. By using cell biological assays and global transcriptional analysis with DNA  ...[more]

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