Genomics

Dataset Information

17

Integrative analysis of gene expression profiling and genomic copy number in Gastrointestinal Stromal Tumors


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Maria Abbondanza Pantaleo   

PROVIDER: GSE20710 | GEO | 2010-08-27

SECONDARY ACCESSION(S): GSE20709GSE20708PRJNA124905

REPOSITORIES: GEO

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Publications

A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number.

Astolfi Annalisa A   Nannini Margherita M   Pantaleo Maria Abbondanza MA   Di Battista Monica M   Heinrich Michael C MC   Santini Donatella D   Catena Fausto F   Corless Christopher L CL   Maleddu Alessandra A   Saponara Maristella M   Lolli Cristian C   Di Scioscio Valerio V   Formica Serena S   Biasco Guido G  

Laboratory investigation; a journal of technical methods and pathology 20100614 9


In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. We report the first study that integrates gene expression profiling and high-resolution genomic copy number analyses in GIST. Fresh tissue specimens from 25 patients with GIST were collected, and gene expression profiling  ...[more]

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