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CLIPseq of hnRNP A1 from the spinal cords of mice with experimental autoimmune encephalomyelitis

ABSTRACT: Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis (MS) a chronic autoimmune disease of the central nervous system. We have observed dysfunction of the RNA binding protein hnRNP A1 in neurons from the brains of patients with MS, and the spinal cords of mice with EAE. Here, we sought to characterize the consequences of EAE-induced dysfunction of hnRNP A1 on the RNAs it binds by using CLIPseq to establish both the normal central nervous system RNA binding profile of hnRNP A1 in the spinal cords of naive mice, and any alterations to the binding profile of hnRNP A1 in the spinal cords of mice with EAE.

ORGANISM(S): Mus musculus

PROVIDER: GSE208093 | GEO | 2024/01/04

REPOSITORIES: GEO

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