Proteomics

Dataset Information

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Mouse brain proteome map of Experimental autoimmune encephalomyelitis (EAE) mouse model


ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS); its cause is unknown. To understand the pathogenesis of MS, researchers often use the experimental autoimmune encephalomyelitis (EAE) mouse model. Here, our aim was to build a proteome map of the biological changes that occur during MS at the major onset sites—the brain and the spinal cord. We performed quantitative proteome profiling in five specific brain regions and the spinal cord of EAE and healthy mice with high-resolution mass spectrometry based on tandem mass tags.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD011428 | Pride | 2019-02-25

REPOSITORIES: pride

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Publications

Quantitative Proteome Analysis of Brain Subregions and Spinal Cord from Experimental Autoimmune Encephalomyelitis Mice by TMT-Based Mass Spectrometry.

Hasan Mahbub M   Min Hophil H   Rahaman Khandoker Asiqur KA   Muresan Anca Raluca AR   Kim Hyeyoon H   Han Dohyun D   Kwon Oh-Seung OS  

Proteomics 20190221 5


Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS); its cause is unknown. To understand the pathogenesis of MS, researchers often use the experimental autoimmune encephalomyelitis (EAE) mouse model. Here, the aim is to build a proteome map of the biological changes that occur during MS at the major onset sites-the brain and the spinal cord. Quantitative proteome profiling is performed in five specific brain regions and the spinal cord of EAE and healthy mice wit  ...[more]

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