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Quantitative proteomic analysis of experimental autoimmune encephalomyelitis mice implicates SUMOylation in multiple sclerosis

ABSTRACT: In this study, we performed quantitative proteomics utilizing a data-independent acquisition (DIA) strategy to investigate the proteome alteration in the brain and spinal cord tissues from mice with experimental autoimmune encephalomyelitis (EAE), a widely-used model for MS.

ORGANISM(S): Mus Musculus

SUBMITTER: Ruibing Chen

PROVIDER: PXD050789 | iProX | Wed Mar 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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Proteome Profiling of Experimental Autoimmune Encephalomyelitis Mouse Model and the Effect of a SUMO E1 Inhibitor.

Du Yingdong Y Yang Linlin L Wang Xiaoxiao X Jiang Na N Zhou Yanting Y Chen Ruibing R Li Hongyan H

Journal of proteome research 20241121 12

Multiple sclerosis (MS) is one of the most common neurodegenerative diseases, causing demyelination and inflammation in the central nervous system. The pathology of MS has been extensively studied using the experimental autoimmune encephalomyelitis (EAE) mouse model. However, the molecular mechanisms are still largely unclear and require further investigation. In this study, we carried out quantitative proteomic analysis of the brain and spinal cord tissues in mice induced with EAE using a data- ...[more]

PMID: 39568369

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